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    Structured Abstract Title Effect of the irrigation fluid temperature on core temperature in Transurethral resection of prostate patients under spinal versus general anaesthesia Study Design Prospective

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    Structured Abstract Title Effect of the irrigation fluid temperature on core temperature in Transurethral resection of prostate patients under spinal versus general anaesthesia Study Design Prospective , randomized control trial Objectives To evaluate and compare the effect of warm and unwarmed irrigation fluid and anaesthetic technique on core temperature in patients undergoing Transurethral resection of prostate . Summary of Background Data Material Methods The present study was conducted in 80 patients belonging to age group18-75 yrs of posted for TURP under general anaesthesia or spinal anaesthesia. Group A General Anaesthesia with irrigation fluid at room temperature Group B GeneralAnaesthesia with irrigation fluid at 37 C Group C Spinal Anaesthesia with irrigation fluid at room temperature Group D Spinal Anaesthesia with irrigation fluid at at 37 C Results Amongst the four Groups, all the subjects showed consistently reduced core temperature which was statistically significant (p0.05) at all time intervals.Core temperatures were lower in the group receiving unwarmed irrigation fluid compared with the prewarmed irrigation fluid group at the end of surgery. The mean decrease in core temperature at the end of surgery 4.2105 F in Group A 1.1105 F. in Group B, 4.2700 F. in Group C, 1.4250 F in Group D .The difference in mean core temperature was not statistically significant in Groups receiving unwarmed fluid . Statistically significant difference in mean core temperature was seen in Group B and Group D. Conclusion Use of prewarm irrigation fluid resulted in lesser drop in core temperature as compared than that receiving unwarmed irrigation fluid. The drop was relatively least in patients under general anaesthesia. Keywords Transurethral prostate resection, core temperature,hypothermia,prewarmed,irrigation fluid. . Effect of the irrigation fluid temperature on core temperature in Transurethral resection of prostate patients under spinal versus general anaesthesia Introduction Preventing unintentional hypothermia for all surgical patients has been an important challenge for anaesthesiologist 1. Despite body temperature been a vital sign , hypothermia during TURP has received relatively little importance in the urology literature2 .Irrigation fluid as a cause of hypothermia during TURP was first reported by Rabke et al3. The consequences of unplanned hypothermia are significant and is well documented in the existing literature 4. The type of anaesthetic technique and the temperature of irrigation fluid best for TURP is still debatable.Spinal anaesthesia is a preferred for TURP 5however general anesthesia is indicated when blockade is counterindicated, fails or is refused by the patient .The type of anaesthetic used also influence the irrigation fluid absorption and also impairs the thermoregulatory mechanisms which contributes to the development of hypothermia6 .Most patients undergoing TURP are elderly which is an important independent risk factor for developing hypothermia which increases susceptibility to intraoperative as well as postoperative complications and delays patient recovery from anaesthesia 6hence increasing the financial burden on the patient .Therefore it is critical to understand the importance of maintaining normothermia in patients specially elderly undergoing surgery . Various stratigies can be used to prevent heat loss and to lower the risk of inadvertent hypothermia associated with administering anaesthesia .Warming of irrigation fluid seems appealing to achieve normothermia7 ,however studies comparing the effect of pre warmed and unwarmed irrigation fluid under different anaesthetic technique to prevent unintended hypothermia have shown conflicting results. The aim of the present study was to determine the effectiveness of warm irrigation fluid in maintaining core body temperature in patients undergoing TURP under spinal versus general anaesthesia in a limited resource setup. Material and Method After approval from Institutional Ethical Committee and written informed consent from the patients,80 patients scheduled for elective TURP were selected. The patients were in the age group of 60-85 years, American Society of Anaesthesiologist I and II. Patients with preexisting major cardiovascular, respiratory or endocrinal diseases, preoperative anaemia, severe electrolyte abnormality, on anticoagulant therapy or existing coagulopathy were excluded. Other exclusion criteria were patients on nitrates, ACE inhibitors or calcium channel blockers, as these medications might interfere with normal thermal regulation.mechanisms.A thorough preoperative evaluation was done for all patients. The patients were kept nil per oral for 6 hours before surgery and received tablet diazepam 10 mg night before and on morning of surgery with a sip of water. In the operation theater after securing intravenous access all patients were preloaded with 500 ml of Ringer lactate. Preoperative baseline vitals such as ECG,NIBP and SPO2 were noted .The temperature of operation theater was noted and kept constant at 23C.The patients were then randomly allocated into any of the four groups. Randomization was done with sealed envelope technique. Group A General Anaesthesia with irrigation fluid at room temperature Group B GeneralAnaesthesia with irrigation fluid at 37 C Group C spinal anaesthesia with irrigation fluid at room temperature Group D spinal anaesthesia with irrigation fluid at at 37 C The patients in Group C and D were administered subarachnoid block in the sitting position using 25 G spinal needle by midline approach and 12.5 mg of hyperbaric bupivacaine was administered The patient was turned to supine position .Level of the block was checked by pinprick method .Patients were covered with theater linen at room temperature during the procedure and were not actively heated. Monopolar resection was performed using cautery with cutting and coagulation setting of 100 and 60 W respectively A well-lubricated resectoscope (Olympus winter and IbeGmbH, Kuchnstr 61, 22045 Hamburg, Germany) and the telescope was used for resection of the prostate. The perfusion pressure was 60 cm of water in all cases.The temperature of the distilled water as irrigating fluid in Group A and Group C was similar to room temperature while in Group B and Group D irrigation fluid was warmed by using incubator (YARCO B.O.D) Yarco sales Pvt. Ltd., New Delhi,India. Before use irrigation fluid was put into irrigation fluid reservoir (sew water bath, scientific equipment works, (India) New Delhi) which was also prewarmed up to 37C. The temperature of the irrigation fluid was measured with a mercury thermometer put inside the reservoir. Statistical analysis –Data were represented in the form of mean standard deviation and analysis was performed utilize SPSS-version 22 (SPSS, Software, IBM Corporation, Amrok, Newyork). P 0.05 was considered to be statistically significant. Nasopharyngeal temperature were recorded over the study period ,comparisions were performed with analysis of variance(ANOVA) with Post hoc comparision adjusted by Tukeys test . Result- Eighty patients were initially enrolled in each group, and none of the patient was excluded from the analysis .There was no statistically significant differences in the groups concerning base line parameters such as age, height, weight, ASA grade, duration of surgery, amount of irrigation fluid used, and ambient temperature in the operating room Table1. Table2 illustrates observed changes in core temperature during the perioperative period. Patients in all the groups who received unwarmed and warmed irrigating fluid demonstrated a significant decrease of core body temperature. In each group temperature changes were highly significant (p.05) .The drop in nasopharyngeal temperature from baseline to the end of surgery was Group A 98.70 F to 93.700F, in Group B 98.7 0 F to 96.70 F, in Group C 98.70F to 94.00 F and in Group D from 98.60 F to 96.70 F. Discussion We found that although the core temperature decreased in all the groups after induction of anaesthesia but the magnitude of hypothermia is not affected by mode of anaesthetic technique with unwarmed irrigant fluid. Although prewarming fluid to 37C did not completely abolish intraoperative hypothermia but definitely reduce its severity in elderly patients undergoing TURP. The incidence was least under general anaesthesia.our study is unique in the way that we studied the effect of prewarmed and unwarmed irrigation fluid on core body temperature under regional as well as general anaesthesia in a single setting that none of the published trials have reported previously. Causes of hypothermia are multifactorial which is influenced by extremes of age, operating room temperature, length and type of surgical procedure, temperature of irrigants and the type of anesthesia8.Several methods of patient warming have been reported in clinical studies to lower the chances of inadvertent hypothermia associated with anaesthesia and surgery9 . Use of irrigation fluid at room temperature as a cause of hypothermia was postulated by Winter etal10 . Similar results were observed by a study conducted in our department11.Hahn et al and Carpenter et al revealed the benefits of using warmed irrigation fluid for endoscopic proceedures12. The recently published National Institute for Health and Clinical Excellence (NICE) guidelines on prevention of peri-operative hypothermia recommends that blood products and fluids administered to patients under anaesthesia should be warmed to 37.0 C 13. Cochrane review has also confirmed that warming intravenous and irrigation fluids appear to keep patient normothermic than those who received unwarmed fluid14 . Conversely, other authors did not confirm this result 15. Warming of irrigation fluid has been found to be effective option to prevent perioperative hypothermia.Our study and that of Dyer and Heathcote16 provide evidence that although the temperature fall was less with prewarmed irrigant it still droped at average of 10 c .The reason for the observation could be the heat loss as the the prewarmed fluid is flushed into the urinary bladder which can be prevented by using continuously warming irrigation system 17. On the other hand, Jaffe et al found no correlation between irrigation fluid temperatures and fall in core temperature in a TURP procedure18 In none of our patients the core temperature fell below 93.7 F. This may be attributed to two factors namely shorter duration of surgery (mean duration between 52.75 5.75 to 57.50 9.67 minutes) and lesser usage of irrigation fluid (Mean volume of irrigation fluid used 6.10 2.63 L to 7.61 3.14L) . According to the study done by Hahn et al limiting surgical time to one hour may prevent hypothermia due to lesser absorption of fluid irrespective of fluid temperature19. We used prewarmed irrigation fluid in Group B and Group D .It is worth mentioning that the drop in on core temperature was less in Group B which could be explained by the work of Gehring and Colleagues,who reported that spontaneously breathing patients under regional anaesthesia absorb more irrigation fluid as compared to the patients receiving general anaesthesia with positive pressure ventilation hence exhibiting much drop in core temperature 20 . However few studies that have considered core temperature during general and regional anesthesia observed a similar incidence and magnitude of hypothermia.21,22 The positive relationship between hypothermia and regional anaesthesia is a common experience in the clinical settings with additional factor being higher block height and advanced age of the patients 23. In the current study the block height achieved was T10 in all the patients and comparable age of the patients in all the group. In the patients of all the groups the nasopharyngeal temperature dropped Regardless of the type of anaesthetic technique used no statistically significant difference was found in the mean nasopharyngeal temperature of patients receiving room temperature irrigation fluid . The mean of difference in core temperature of the patients who received warm irrigation fluid under general anaesthesia was (1.11 .28) which was significantly less ( P.000) as compared to other groups. Although in this study the core body temperature was measured by nasopharyngeal route which is recommended as a reliable method for measuring core body temperature additionally, measurement of the skin temperatures on limbs and trunk in addition to core temperature, could have helped us in estimating mean body temperature and total heat body content.(24)Another limitation of our study was that when the irrigation fluid is warmed from 17C to 37C there is corresponding change in the density and dynamic fluidity of the irrigating fluid25 .This aspect of fluid dynamic change should also be considered when it is warmed. In our study we did not look into this aspect . Although the findings of the our study cannot be extrapolated to all patients ,we have demonstrated that intraoperative hypothermia is more common in usual practice than we recorded. both the spinal as well as general anaesthesia leads to perioperative hypothermia the incidence of which is least when prewarmed irrigation fluid is used in patients under general anaesthesia.However this cost effective method of prewarming of irrigation fluid should be incorporated routinely in patients undergoing TURP under general or spinal anaesthesia offering decrease post operative thermal discomfort . References 1.Sessler D. I. Mild perioperative hypothermia.N Engl J Med.199733617301737 2. Vaughan MS, Vaughan RW, Cork RC. Postoperative hypothermia in adults relationship of age, anesthesia, and shivering to rewarming.AnesthAnalg19816074651 3. RABKE HB, JENICEK JA, KHOURI E., Hypothermia associated with transurethral resection of the prostate.J Urol.1962 Mar874474498 4.Evans JW, Singer M, Chapple CR, Macartney N, Walke JM, Milroy EJ. Haemodynamic evidence for cardiac stress during transurethral prostatectomy. Br Med J 1992304666-71 5.Hatch PD – Surgical and anaesthetic considerations in transurethral resection of the prostate. Anaesth Intensive Care, 198715203-211 6. Okeke LI. Effect of warm intravenous and irrigating fluids on body temperature during transurethral resection of the prostate gland.BMC Urol.2007715 7.Dobson PM, Caldicott LD, Gerrish SP, Cole JR, Channer KS. Changes in haemodynamic variables during transurethral resection of the prostate comparison of general and spinal anaesthesia.Br J Anaesth.199472(3)26771. 8. Board, T.N. and Srinivasan, M.S. 2008. The effect of irrigation fluid temperature on core body temperature in arthroscopic shoulder surgery. Arch. Orthop. Trauma Surg. 128, 531-533 9. Kim, Y.S., Lee, J.Y., Yang, S.C., Song, J.H., Koh, H.S. and Park, W.K. 2009. Comparative study of the influence of room temperature and warmed fluid irrigation on body temperature in arthroscopic shoulder surgery. Arthroscopy 25(1), 24-29. K 10. Winter M. Effects of irrigation fluid warming on hypothermia during urologic surgery. Urol Nurs. 199414(1)6-8. 12. Carpenter AA. Hypothermia during transurethral resection of prostate. Urology 198423122-4. 13. NICE (National Institute for Health and Clinical Excellence). 2008. Clinical Practice Guideline. The Management of Inadvertent Perioperative Hypothermia In Adults. National Collaborating Centre for Nursing and Supportive Care. April.1567. 14. Campbell G, Alderson P, Smith AF, Warttig S. Warming of intravenous and irrigation fluids for preventing inadvertent perioperative hypothermia. Cochrane Database of Systematic Reviews 2015, Issue 4. Art. No. CD009891. 15. Taufan Tenggara, Djoko Rahardjo Effect of irrigating fluid temperature on core body temperature during transurethral resection of the prostate Med J Indones 2005 14 152-6 16. Dyer PM, Heathcote PS. Reduction of heat loss during transurethral resection of the prostate.Anaesth Intensive Care.198614126. 17. Moore SS, Green CR, Wang FL, Pandit SK, Hurd WW. The role of irrigation in the development of hypothermia during laparoscopic surgery.Am J Obstet Gynecol.1997176598602. 18. Jaffe JS, McCullough TC, Harkaway RC, Ginsberg PC. Effects of irrigation fluid temperature on core body temperature during transurethral resection of the prostate.Urology.200157107881. 19 Hahn RG. Fluid absorption in endoscopic surgery.Br J Anaesth.200696820. 20. Gehring H, Nahm W, Baerwald J et al. Irrigation fluid absorption during transurethral resection of prostate Spinal vs General anaesthesia. Acta Anaesthesiol Scand 1999 43 458-63 21Frank SM, Shir Y, Raja SN, Fleisher LA, Beattie C Core hypothermia and skin-surface temperature gradients Epidural vs. general anesthesia and the effects of age. Anesthesiology 1994 805028 22.Jenkins J, Fox J, Sharwood-Smith G Changes in body heat during transvesical prostatectomy A comparison of general and epidural anesthesia. Anaesthesia 1983 3874853 23. Leslie K, Sessler DI Reduction in the shivering threshold is proportional to spinal block height. A nesthesiology 1996 84132731. 24.Frank SM, Shir Y, Raja SN, Fleisher LA, Beattie C. Core hypothermia and skin-surface temperature gradients. Epidural versus general anesthesia and the effects of age. Anesthesiology. 1994 Mar80(3)502-8. 25. de Freitas Fonseca M, Andrade CM, Jr, de Mello MJ, Crispi CP. Effect of temperature on fluidity of irrigation fluids.Br J Anaesth.2011106516 Table1 Demographic Profile and the operative details of the patients Table 2 Temperature Changes (oF) Mean S.D. . GroupsPre inductionInduction /InjectionIntubation /Time of effectStart of surgery15 minutes30 minutes45 minutes60 minutesEnd of surgeryP valueA98.46 0.1898.33 0.1997.70 0.3897.8 0.196.8 0.896.6 0.296.2 0.995.8 0.194.2 0.2P.05B98.55 0.1298 0.1498 0.1598.6 0.897.5 0.697.9 0.697.1 0.997.8 0.697.4 0.8P.05C98.56 0.0998.53 0.1098.23 0.1097.6 0.596.5 0796.8 0.695.6 0.594.7 0.294.6 0.5P.o5D98.56 0.0698.55 0.0698.39 0.1098.8 0.198 0.397.6 0.497.4 0.797.2 0.897.3 0.6P.05 PAGE 7 Y, 4IsNXp
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    Structured Abstract Title Effect of the irrigation fluid temperature on core temperature in Transurethral resection of prostate patients under spinal versus general anaesthesia Study Design Prospective. (2019, Mar 09). Retrieved from

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